In vivo visualization of lymphatic tissue
Patent Number: US20140121512
Executive Summary:
General Description:
The conventional immunohistochemistry method which has been heavily relied upon to identify lymphatic vessels involves multiple steps of tissue fixation and antibody staining, which are both time consuming and labor intensive. Moreover, this method works with dead tissues and does not generate real time information on lymphatic vessels in the context of their natural morphology, state, or interaction with other components in the local living environment. Scientists at University of California have come up with a new method that allows imaging of lymphatic tissue in live cells in vivo.
Strengths:
Weaknesses:
Patent Status:
Inventor Bio: Lu Chen
https://optometry.berkeley.edu/people/lu-chen-md-phd/
Executive Summary:
- Invention Type: Diagnostic and Device
- Patent Status: Pending
- Patent Link: https://patents.google.com/patent/US20140121512/
- Research Institute: University of California, Berkeley
- Disease Focus: In cancer cases that cornea is affected
- Basis of Invention: Live imaging of lymphatic tissue
- How it works: Contacting the ocular region with a detectably-labeled lymphatic tissue-specific dye (i.e. fluorescently-labeled lymphatic tissue-specific dye, e.g., FITC or rhodamine labeled dextran, and detecting the labeled dye to visualize lymphatic tissue in the region) and detecting the labeled dye to visualize lymphatic tissue in the ocular region. The system for visualizing lymphatic tissue in an ocular region of a living subject is comprised of a detectably-labeled lymphatic tissue-specific dye; and a device for detecting a signal from the detectable label in the ocular region
- Lead Challenge Inventor: Lu Chen
- Inventors: Lu Chen, Don Yuen
- Development Stage: in vivo (mice)
- Novelty: The conventional immunohistochemistry method that has been heavily relied upon to identify lymphatic vessels involves multiple steps of tissue fixation and antibody staining, which are both time consuming and labor intensive. Moreover, this method works with dead tissues and does not generate real time information on lymphatic vessels in the context of their natural morphology, state, or interaction with other components in the local living environment. Since the tissue is excised at a fixed time point, this method cannot be used for time-course study on the same tissue or subject for a certain period of time. Nevertheless, lymphangiogenesis (the development of new lymphatic vessels) is a dynamic and progressive process, and it is critical to obtain such longitudinal information for many studies, whether to track lymphatic changes from an early to a late stage, or to evaluate lymphatic responses to a biological or pharmaceutical intervention. The current invention is designed to bypass such limitations
- Clinical Applications: Live imaging of lymphatic tissue
General Description:
The conventional immunohistochemistry method which has been heavily relied upon to identify lymphatic vessels involves multiple steps of tissue fixation and antibody staining, which are both time consuming and labor intensive. Moreover, this method works with dead tissues and does not generate real time information on lymphatic vessels in the context of their natural morphology, state, or interaction with other components in the local living environment. Scientists at University of California have come up with a new method that allows imaging of lymphatic tissue in live cells in vivo.
Strengths:
- Novel approach
Weaknesses:
- Requires larger trials and toxicity studies
Patent Status:
- Priority date: 2012-10-31
- Filing date: 2013-10-31
- Publication date: 2014-05-01
- Grant date: Legal status: pending
Inventor Bio: Lu Chen
https://optometry.berkeley.edu/people/lu-chen-md-phd/
