Preparations of poly(lactic-co-glycolic acid)/polydopamine core/shell hybrid nanoparitcle for photothermal applications
Patent Number: US20170095558
Executive Summary:
General Description:
Several different types of nanostructures have been utilized as substrates in photothermal therapy methodology, including aggregated gold nanoparticles, gold nanoshells, gold nanocages, core-free Au/Ag dendrites, gold nanorods, carbon nanotubes, and graphite. Despite their advantages, existing photothermal substrates present challenges, particularly for in vivo applications. For instance, gold nanorods are often prepared by a seed-mediated synthesis and include a bilayer capping of cetyltrimethylammonium bromide (CTAB), which shows cytotoxicity, thus limiting the clinical application. In addition, the unsatisfied payload-carrying capacity of known photothermal substrates has hindered their clinical translation. In addition, known materials are generally not biodegradable, and as such will either remain in the subject's body or, if expelled, need to be recovered to avoid release into the environment.
To address these gaps, investigators at University of South Carolina have designed a biodegradable and biocompatible material that can integrate both photothermal therapy and drug delivery modules into one system.
Strengths:
Weaknesses:
Patent Status:
Inventor Bio: Peisheng Xu
http://sccp.sc.edu/Peisheng-Xu
Executive Summary:
- Invention Type: Diagnostic/Therapeutic
- Patent Status: Publication date: Apr 6, 2017
- Patent: US20170095558
- Link: https://www.google.com/patents/US20170095558/
- Research Institute: University of South Carolina
- Disease Focus: Cancer
- Basis of Invention: A photothermal substrate is located in the vicinity of a targeted cell mass or tissue and excited with electromagnetic radiation at a specific wavelength band. This activation brings the substrate to an excited state where it then releases energy in the form of heat. The local increase in temperature can destroy diseased cells in the vicinity
- How it works: The hybrid nanoparticle includes a poly(lactide-co-glycolic acid) core and a polydopamine shell. The hybrid nanoparticle can be loaded with an active agent such as an anti-cancer agent. The hybrid nanoparticles can include detection agents, targeting agents, etc.
- Lead Challenge Inventor: Peisheng Xu
- Inventors: Peisheng Xu, Huacheng He
- Development Stage: Methods of preparation have not been tested in vitro or in vivo yet
- Novelty: Biodegradable and biocompatible nanoparticle
- Clinical Applications: This mode of delivery with improved formulation allows for detecting or targeting cancer cells
General Description:
Several different types of nanostructures have been utilized as substrates in photothermal therapy methodology, including aggregated gold nanoparticles, gold nanoshells, gold nanocages, core-free Au/Ag dendrites, gold nanorods, carbon nanotubes, and graphite. Despite their advantages, existing photothermal substrates present challenges, particularly for in vivo applications. For instance, gold nanorods are often prepared by a seed-mediated synthesis and include a bilayer capping of cetyltrimethylammonium bromide (CTAB), which shows cytotoxicity, thus limiting the clinical application. In addition, the unsatisfied payload-carrying capacity of known photothermal substrates has hindered their clinical translation. In addition, known materials are generally not biodegradable, and as such will either remain in the subject's body or, if expelled, need to be recovered to avoid release into the environment.
To address these gaps, investigators at University of South Carolina have designed a biodegradable and biocompatible material that can integrate both photothermal therapy and drug delivery modules into one system.
Strengths:
- If it proves that it is biodegradable and biocompatible in vivo then this is one of the strength of this photothermal nanoparticle
Weaknesses:
- Has not been tested in vitro or in vivo yet
Patent Status:
- Priority date: Apr 6, 2017
- Filing date: Sep 19, 2016
- Publication date: Apr 27, 2017
Inventor Bio: Peisheng Xu
http://sccp.sc.edu/Peisheng-Xu
