Anionic lipids and lipid nano-structures and methods of producing and using same
Patent Number: US8420118
Executive Summary:
General Description:
Availability and safety of blood is still a major concern in blood transfusion medicine. Instead, formulations that mimic red blood cells could be used. One approach to do so is the encapsulation of hemoglobin as an oxygen carrier in liposomes for the efficient delivery of oxygen. Typically, anionic phospholipids are used as liposomal encapsulation. However, phospholipids rapidly interact with biological membranes. This invention describes the composition of anionic lipids without a phosphogroup for the liposomal encapsulation of hemoglobin, resulting in reduced toxic effects while maintaining high encapsulation and delivery efficiencies.
Strengths:
Patent Status:
Inventor Bio: Vibhudutta Awasthi
http://pharmacy.ouhsc.edu/people/view.asp?User=vawasthi
Executive Summary:
- Invention Type: Therapeutic
- Patent Status: Active
- Patent Link: https://patents.google.com/patent/US8420118/
- Research Institute: University of Oklahoma
- Disease Focus: Cancer
- Basis of Invention: Liposomal structures of anionic lipids without phosphogroup
- How it works: Hemoglobin is an ideal oxygen carrier that can be an alternative to blood transfusion for the delivery of oxygen. Liposomal structures can be used for the compartmentalization of hemoglobin. Phospholipids for liposomal encapsulation rapidly interact with biological membrane, resulting in toxic side-effects. The current invention describes the molecular structure of anionic lipids without phosphogroup for efficient encapsulation of hemoglobin while keeping toxicity in check
- Lead Challenge Inventor: Vibhudutta Awasthi
- Inventors: Vibhudutta Awasthi, Pallavi Lagisetty
- Development Stage: Pre-clinical
- Novelty:
- Use of anionic lipids without phosphogroup rather than phospholipids
- Use of anionic lipids without phosphogroup rather than phospholipids
- Clinical Applications:
- Encapsulation of therapeutic compounds in liposomes, such as hemoglobin as oxygen carrier in blood transfusion medicine
- Encapsulation of therapeutic compounds in liposomes, such as hemoglobin as oxygen carrier in blood transfusion medicine
General Description:
Availability and safety of blood is still a major concern in blood transfusion medicine. Instead, formulations that mimic red blood cells could be used. One approach to do so is the encapsulation of hemoglobin as an oxygen carrier in liposomes for the efficient delivery of oxygen. Typically, anionic phospholipids are used as liposomal encapsulation. However, phospholipids rapidly interact with biological membranes. This invention describes the composition of anionic lipids without a phosphogroup for the liposomal encapsulation of hemoglobin, resulting in reduced toxic effects while maintaining high encapsulation and delivery efficiencies.
Strengths:
- High encapsulation efficiency
- No interaction with biological membranes
- Efficient oxygen delivery in blood transfusion medicine
Patent Status:
- Filing date: 2009-09-10
Inventor Bio: Vibhudutta Awasthi
http://pharmacy.ouhsc.edu/people/view.asp?User=vawasthi
