Calcium phosphate nanowhisker particles, method of making and using the same
Patent Number: US8906415
Executive Summary:
General Description:
A process for forming a calcium phosphate nanowhisker particle, comprising:
i) exposing a mixture of a soluble calcium, a soluble phosphate, and urea to microwave energy for a predetermined period of time and at a predetermined energy level sufficient to cause an exothermic reaction; and thereafter,
ii) cooling the mixture of step i) so that calcium phosphate nanowhiskers having a length:diameter aspect ratio of greater than about 1:1 are precipitated in a molten salt bath, wherein
the mixture comprises an aqueous solution of Ca(NO3)2 and an aqueous solution of KH2PO4 at a ratio of about 1:0.38, by weight.
Strengths:
The nanowhisker particles are stable, provide immediate and sustained release, are biocompatible, biodegradable, and have non-toxic and non-acidic degradation products
Weaknesses:
Patent Status:
Inventor Bio: Sarit Bhaduri
http://www.eng.utoledo.edu/mime/faculty_staff/faculty/sbhaduri/
Executive Summary:
- Invention Type: Diagnostic/Therapeutic
- Patent Status: Active
- Patent Link: https://patents.google.com/patent/US8906415
- Research Institute: University of Toledo
- Disease Focus: Cancer
- Basis of Invention: A calcium phosphate nanowhisker particle having a high aspect ratio.
- How it works: A method of diagnosing genitourinary cancers based on thromboxane receptor β (TPβ) levels in liquid samples, as well as a kit for this diagnostic tool. This is a more sensitive and more specific early detection tool
- Lead Challenge Inventor: Sarit Bhaduri
- Inventors: Sarit Bhaduri, Darcy E. Wagner
- Development Stage: Pre-clinical, Validation of the lead peptide in xenograft mouse model
- Novelty:
- Improved nanoparticle formulation for localized, less toxic active agent delivery
- Clinical Applications:
- Can be used for localized, less toxic chemotherapy delivery
General Description:
A process for forming a calcium phosphate nanowhisker particle, comprising:
i) exposing a mixture of a soluble calcium, a soluble phosphate, and urea to microwave energy for a predetermined period of time and at a predetermined energy level sufficient to cause an exothermic reaction; and thereafter,
ii) cooling the mixture of step i) so that calcium phosphate nanowhiskers having a length:diameter aspect ratio of greater than about 1:1 are precipitated in a molten salt bath, wherein
the mixture comprises an aqueous solution of Ca(NO3)2 and an aqueous solution of KH2PO4 at a ratio of about 1:0.38, by weight.
Strengths:
The nanowhisker particles are stable, provide immediate and sustained release, are biocompatible, biodegradable, and have non-toxic and non-acidic degradation products
Weaknesses:
- Other groups are developing calcium nanoparticles for drug delivery
Patent Status:
- Filing date – 2012-10-26
- Publication date – 2014-12-09
- Grant date – 2014-12-09
Inventor Bio: Sarit Bhaduri
http://www.eng.utoledo.edu/mime/faculty_staff/faculty/sbhaduri/
