Spatially offset Raman spectroscopy of layered soft tissues and applications of same
Patent Numbers: US9289130 and US20140140594

Executive Summary:
  • Invention Type: Diagnostic and Device
  • Patent Status: US Grant
  • Patent Link: https://patents.google.com/patent/US9289130/, https://www.google.com/patents/US20140140594
  • Research Institute: Vanderbilt University
  • Disease Focus: Breast cancer
  • Basis of Invention: Discriminates soft biological tissues
  • How it works: Illuminates soft biological tissues, collecting Raman scattering light scattered from the tissue, obtaining a spatially offset Raman spectrum from the collected light and identifying the tissue
  • Lead Challenge Inventor: Anita Mahadevan-Jansen
  • Inventors: Anita Mahadevan-Jansen, Matthew D. Keller, Mark C. Kelley
  • Development Stage: Tested on breast tissue samples in vitro
  • Novelty: Novel use of SORS to discriminate multiple layers of soft tissue
  • Clinical Applications: Surgical margin assessment for diagnosis and therapy guidance

General Description:
SORS could be used to evaluate margin status during breast conserving therapy (BCT). It has been shown that the presence of tumor in the removed tissue within 1-2 mm of the surgical margin is strongly correlated with the risk of local recurrence. Margins therefore play a key role in the prognosis of the patient with respect to local recurrence of breast cancer and are directly correlated to the success of BCT as a treatment modality. SORS allows the discrimination of two layers of soft tissue, specifically normal breast tissue overlying breast tumor.

Future Directions:
  • Clinical validation

Strengths:
  • Faster than the serial sectioning with histopathology
  • Can be used for the diagnosis of breast cancer and guidance of therapy or margin assessment

Patent Status:
Legal Status: Active
  • Priority dates: 2008.12.05 and 2012.11.20
  • Filing dates: 2015.02.12 and 2013.11.20
  • Publication dates: 2016.03.22 and 2014.5.22
  • Grant date: 2016.03.22

Publication PMID: 19021389, 19340173, 21806286, 20537228

Publications:
Majumder SK, Keller MD, Boulos FI, Kelley MC, Mahadevan-Jansen A. Comparison of autofluorescence, diffuse reflectance, and Raman spectroscopy for breast tissue discrimination. J Biomed Opt. 2008 Sep-Oct;13(5):054009. doi: 10.1117/1.2975962.

Keller MD, Majumder SK, Mahadevan-Jansen A. Spatially offset Raman spectroscopy of layered soft tissues. Opt Lett. 2009 Apr 1;34(7):926-8.

Keller MD, Vargis E, de Matos Granja N, Wilson RH, Mycek MA, Kelley MC, Mahadevan-Jansen A. Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation. J Biomed Opt. 2011 Jul;16(7):077006. doi: 10.1117/1.3600708.

Keller MD, Wilson RH, Mycek MA, Mahadevan-Jansen A. Monte Carlo model of spatially offset Raman spectroscopy for breast tumor margin analysis. Appl Spectrosc. 2010 Jun;64(6):607-14. doi: 10.1366/000370210791414407.

Inventor Bio: Anita Mahadevan-Jansen
https://engineering.vanderbilt.edu/bio/anita-mahadevan-jansen