Spatially offset Raman spectroscopy of layered soft tissues and applications of same
Patent Numbers: US9289130 and US20140140594
Executive Summary:
General Description:
SORS could be used to evaluate margin status during breast conserving therapy (BCT). It has been shown that the presence of tumor in the removed tissue within 1-2 mm of the surgical margin is strongly correlated with the risk of local recurrence. Margins therefore play a key role in the prognosis of the patient with respect to local recurrence of breast cancer and are directly correlated to the success of BCT as a treatment modality. SORS allows the discrimination of two layers of soft tissue, specifically normal breast tissue overlying breast tumor.
Future Directions:
Strengths:
Patent Status:
Legal Status: Active
Publication PMID: 19021389, 19340173, 21806286, 20537228
Publications:
Majumder SK, Keller MD, Boulos FI, Kelley MC, Mahadevan-Jansen A. Comparison of autofluorescence, diffuse reflectance, and Raman spectroscopy for breast tissue discrimination. J Biomed Opt. 2008 Sep-Oct;13(5):054009. doi: 10.1117/1.2975962.
Keller MD, Majumder SK, Mahadevan-Jansen A. Spatially offset Raman spectroscopy of layered soft tissues. Opt Lett. 2009 Apr 1;34(7):926-8.
Keller MD, Vargis E, de Matos Granja N, Wilson RH, Mycek MA, Kelley MC, Mahadevan-Jansen A. Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation. J Biomed Opt. 2011 Jul;16(7):077006. doi: 10.1117/1.3600708.
Keller MD, Wilson RH, Mycek MA, Mahadevan-Jansen A. Monte Carlo model of spatially offset Raman spectroscopy for breast tumor margin analysis. Appl Spectrosc. 2010 Jun;64(6):607-14. doi: 10.1366/000370210791414407.
Inventor Bio: Anita Mahadevan-Jansen
https://engineering.vanderbilt.edu/bio/anita-mahadevan-jansen
Executive Summary:
- Invention Type: Diagnostic and Device
- Patent Status: US Grant
- Patent Link: https://patents.google.com/patent/US9289130/, https://www.google.com/patents/US20140140594
- Research Institute: Vanderbilt University
- Disease Focus: Breast cancer
- Basis of Invention: Discriminates soft biological tissues
- How it works: Illuminates soft biological tissues, collecting Raman scattering light scattered from the tissue, obtaining a spatially offset Raman spectrum from the collected light and identifying the tissue
- Lead Challenge Inventor: Anita Mahadevan-Jansen
- Inventors: Anita Mahadevan-Jansen, Matthew D. Keller, Mark C. Kelley
- Development Stage: Tested on breast tissue samples in vitro
- Novelty: Novel use of SORS to discriminate multiple layers of soft tissue
- Clinical Applications: Surgical margin assessment for diagnosis and therapy guidance
General Description:
SORS could be used to evaluate margin status during breast conserving therapy (BCT). It has been shown that the presence of tumor in the removed tissue within 1-2 mm of the surgical margin is strongly correlated with the risk of local recurrence. Margins therefore play a key role in the prognosis of the patient with respect to local recurrence of breast cancer and are directly correlated to the success of BCT as a treatment modality. SORS allows the discrimination of two layers of soft tissue, specifically normal breast tissue overlying breast tumor.
Future Directions:
- Clinical validation
Strengths:
- Faster than the serial sectioning with histopathology
- Can be used for the diagnosis of breast cancer and guidance of therapy or margin assessment
Patent Status:
Legal Status: Active
- Priority dates: 2008.12.05 and 2012.11.20
- Filing dates: 2015.02.12 and 2013.11.20
- Publication dates: 2016.03.22 and 2014.5.22
- Grant date: 2016.03.22
Publication PMID: 19021389, 19340173, 21806286, 20537228
Publications:
Majumder SK, Keller MD, Boulos FI, Kelley MC, Mahadevan-Jansen A. Comparison of autofluorescence, diffuse reflectance, and Raman spectroscopy for breast tissue discrimination. J Biomed Opt. 2008 Sep-Oct;13(5):054009. doi: 10.1117/1.2975962.
Keller MD, Majumder SK, Mahadevan-Jansen A. Spatially offset Raman spectroscopy of layered soft tissues. Opt Lett. 2009 Apr 1;34(7):926-8.
Keller MD, Vargis E, de Matos Granja N, Wilson RH, Mycek MA, Kelley MC, Mahadevan-Jansen A. Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation. J Biomed Opt. 2011 Jul;16(7):077006. doi: 10.1117/1.3600708.
Keller MD, Wilson RH, Mycek MA, Mahadevan-Jansen A. Monte Carlo model of spatially offset Raman spectroscopy for breast tumor margin analysis. Appl Spectrosc. 2010 Jun;64(6):607-14. doi: 10.1366/000370210791414407.
Inventor Bio: Anita Mahadevan-Jansen
https://engineering.vanderbilt.edu/bio/anita-mahadevan-jansen
