Methods of detecting ovarian cancer
Patent Number: US9297814
Executive Summary:
General Description:
Ovarian cancer has a high fatality rate due to the late stage of presentation. Therefore, an early diagnosis of ovarian cancer is critical and the need for biomarkers for early detection is urgent. The current invention describes an association of increased serum calcium levels and the likelihood of the adnexal mass of a female subject to be malignant. The diagnostic is preoperative and can be done by collecting a blood or serum sample.
Strengths:
Weaknesses:
Patent Status:
Inventor Bio: Gary G. Schwartz
http://www.wakehealth.edu/News-and-Media/Medical-Experts/Schwartz-Gary-G.htm
Executive Summary:
- Invention Type: Diagnostic
- Patent Status: Active
- Patent Link: https://patents.google.com/patent/US9297814/
- Research Institute: University of Wisconsin, Wake Forest University
- Disease Focus: Ovarian cancer
- Basis of Invention: Chemical analysis of blood sample
- How it works: The invention presents a preoperative method to determine whether the adnexal mass of a female subject is malignant or benign. Ovarian cancers express parathyroid hormone-related protein, which raises serum calcium levels. A blood sample is collected and serum calcium and albumin levels are determined. Comparison of the total levels to a multivariable generalized additive predictive model, that takes age and body mass as covariates, provides a predictive score to determine the likelihood whether the adnexal mass is benign or malignant
- Lead Challenge Inventor: Gary G. Schwartz
- Inventors: Halcyon Gerald Skinner, Gary G. Schwartz
- Development Stage: Pre-clinical (human sample data)
- Novelty:
- Novel serum biomarker to detect ovarian cancer
- Clinical Applications:
- Preoperative diagnostic for ovarian cancer
General Description:
Ovarian cancer has a high fatality rate due to the late stage of presentation. Therefore, an early diagnosis of ovarian cancer is critical and the need for biomarkers for early detection is urgent. The current invention describes an association of increased serum calcium levels and the likelihood of the adnexal mass of a female subject to be malignant. The diagnostic is preoperative and can be done by collecting a blood or serum sample.
Strengths:
- Pre-operative
- Novel biomarkers
Weaknesses:
- Calcium/albumin are involved in a wide range of physiological processes
Patent Status:
- Filing date: 2014-01-06
Inventor Bio: Gary G. Schwartz
http://www.wakehealth.edu/News-and-Media/Medical-Experts/Schwartz-Gary-G.htm
