Particles for imaging
Patent Number: US9446150
Executive Summary:
General Description:
Nanoparticles can serve as targeted agents for imaging or drug delivery through surface modifications. They allow the delivery of high concentration of drugs and imaging agents to a specific disease site, reducing systemic side effects and offering the opportunity to increase the efficacy of therapy and imaging. The composition of the nanoparticle is essential to facilitate non-invasive imaging and improve drug targeting.
Scientific Progress:
Validation of several particles in various experimental models of cancer and heart diseases, for imaging and treatment
Future Directions:
Patent Status:
Legal Status: Active, expire 2029.09.26
Publication PMID: 25652900, 25600969, 25553103, 23918207, 23771914, 22229462, 20585027, 21121304, 20586031
Selected Publications:
Wang K, Pan D, Schmieder AH, Senpan A, Hourcade DE, Pham CT, Mitchell LM, Caruthers SD, Cui G, Wickline SA, Shen B, Lanza GM. Synergy between surface and core entrapped metals in a mixed manganese-gadolinium nanocolloid affords safer MR imaging of sparse biomarkers. Nanomedicine. 2015 Apr;11(3):601-9. doi: 10.1016/j.nano.2014.12.009. Epub 2015 Jan 31.
Pan D, Kim B, Hu G, Gupta DS, Senpan A, Yang X, Schmieder AH, Swan C, Wickline SA, Tomasson MH, Lanza GM. A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy. Nanomedicine (Lond). 2015 Jan;10(2):241-51. doi: 10.2217/nnm.14.101.
Zhang R, Pan D, Cai X, Yang X, Senpan A, Allen JS, Lanza GM, Wang LV. alphaVbeta3-targeted copper nanoparticles incorporating an Sn 2 lipase-labile fumagillin prodrug for photoacoustic neovascular imaging and treatment. Theranostics. 2015 Jan 1;5(2):124-33. doi: 10.7150/thno.10014. eCollection 2015.
Schmieder AH, Wang K, Zhang H, Senpan A, Pan D, Keupp J, Caruthers SD, Wickline SA, Shen B, Wagner EM, Lanza GM. Characterization of early neovascular response to acute lung ischemia using simultaneous (19)F/ (1)H MR molecular imaging. Angiogenesis. 2014 Jan;17(1):51-60. doi: 10.1007/s10456-013-9377-2. Epub 2013 Aug 6.
Schmieder AH, Winter PM, Williams TA, Allen JS, Hu G, Zhang H, Caruthers SD, Wickline SA, Lanza GM. Molecular MR imaging of neovascular progression in the Vx2 tumor with αvβ3-targeted paramagnetic nanoparticles. Radiology. 2013 Aug;268(2):470-80. doi: 10.1148/radiol.13120789. Epub 2013 Jun 14.
Pan D, Cai X, Yalaz C, Senpan A, Omanakuttan K, Wickline SA, Wang LV, Lanza GM. Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles. ACS Nano. 2012 Feb 28;6(2):1260-7. doi: 10.1021/nn203895n. Epub 2012 Jan 20.
Boles KS, Schmieder AH, Koch AW, Carano RA, Wu Y, Caruthers SD, Tong RK, Stawicki S, Scott MJ, Zhang H, Reynolds BA, Wickline SA, Lanza GM. MR angiogenesis imaging with Robo4- vs. alphaVbeta3-targeted nanoparticles in a B16/F10 mouse melanoma model. FASEB J. 2010 Nov;24(11):4262-70. doi: 10.1096/fj.10-157933. Epub 2010 Jun 28.
Pan D, Pramanik M, Senpan A, Wickline SA, Wang LV, Lanza GM. A facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging. J Nanosci Nanotechnol. 2010 Dec;10(12):8118-23.
Kassner A, Thornhill RE, Liu F, Winter PM, Caruthers SD, Wickline SA, Lanza GM. Assessment of tumor angiogenesis: dynamic contrast-enhanced MRI with paramagnetic nanoparticles compared with Gd-DTPA in a rabbit Vx-2 tumor model. Contrast Media Mol Imaging. 2010 May-Jun;5(3):155-61. doi: 10.1002/cmmi.380.
Inventor Bio: Gregory M. Lanza
https://cardiology.wustl.edu/faculty/gregory-m-lanza-md-phd-facc/
Executive Summary:
- Invention Type: Diagnostic/Therapeutic
- Patent Status: US Grant
- Patent Link: https://patents.google.com/patent/US9446150/
- Research Institute: Washington University in St Louis
- Disease Focus: Cancer and heart disease
- Basis of Invention: Nanoparticles that can be used for imaging and drug delivery simultaneously
- How it works: Particles comprise an outer layer formed over an inner metallic core. The outer layer comprises a metal, and can also include a therapeutic agent or an imaging agent detectable by MRI, NMR, x-ray, CT and spectral CT imaging among other
- Lead Challenge Inventor: Gregory M. Lanza
- Inventors: Samuel A. Wickline, Dipanjan Pan, Angana Senpan, Gregory M. Lanza
- Development Stage: Preclinical
- Novelty:
- The method for making the particles
- The particles can be used for both imaging and drug delivery
- Clinical Applications:
- Visualizing a pathology and controlling the local delivery of drug
General Description:
Nanoparticles can serve as targeted agents for imaging or drug delivery through surface modifications. They allow the delivery of high concentration of drugs and imaging agents to a specific disease site, reducing systemic side effects and offering the opportunity to increase the efficacy of therapy and imaging. The composition of the nanoparticle is essential to facilitate non-invasive imaging and improve drug targeting.
Scientific Progress:
Validation of several particles in various experimental models of cancer and heart diseases, for imaging and treatment
Future Directions:
- Clinical validation
- The combination of non-invasive diagnostic imaging and targeted drug delivery for personalized therapy
- Competition with the other theranostic agents (some in clinical development)
Patent Status:
Legal Status: Active, expire 2029.09.26
- Priority date: 2007.10.09
- Filing date: 2008.10.09
- Publication date: 2016.09.20
- Grant date: 2016.09.20
Publication PMID: 25652900, 25600969, 25553103, 23918207, 23771914, 22229462, 20585027, 21121304, 20586031
Selected Publications:
Wang K, Pan D, Schmieder AH, Senpan A, Hourcade DE, Pham CT, Mitchell LM, Caruthers SD, Cui G, Wickline SA, Shen B, Lanza GM. Synergy between surface and core entrapped metals in a mixed manganese-gadolinium nanocolloid affords safer MR imaging of sparse biomarkers. Nanomedicine. 2015 Apr;11(3):601-9. doi: 10.1016/j.nano.2014.12.009. Epub 2015 Jan 31.
Pan D, Kim B, Hu G, Gupta DS, Senpan A, Yang X, Schmieder AH, Swan C, Wickline SA, Tomasson MH, Lanza GM. A strategy for combating melanoma with oncogenic c-Myc inhibitors and targeted nanotherapy. Nanomedicine (Lond). 2015 Jan;10(2):241-51. doi: 10.2217/nnm.14.101.
Zhang R, Pan D, Cai X, Yang X, Senpan A, Allen JS, Lanza GM, Wang LV. alphaVbeta3-targeted copper nanoparticles incorporating an Sn 2 lipase-labile fumagillin prodrug for photoacoustic neovascular imaging and treatment. Theranostics. 2015 Jan 1;5(2):124-33. doi: 10.7150/thno.10014. eCollection 2015.
Schmieder AH, Wang K, Zhang H, Senpan A, Pan D, Keupp J, Caruthers SD, Wickline SA, Shen B, Wagner EM, Lanza GM. Characterization of early neovascular response to acute lung ischemia using simultaneous (19)F/ (1)H MR molecular imaging. Angiogenesis. 2014 Jan;17(1):51-60. doi: 10.1007/s10456-013-9377-2. Epub 2013 Aug 6.
Schmieder AH, Winter PM, Williams TA, Allen JS, Hu G, Zhang H, Caruthers SD, Wickline SA, Lanza GM. Molecular MR imaging of neovascular progression in the Vx2 tumor with αvβ3-targeted paramagnetic nanoparticles. Radiology. 2013 Aug;268(2):470-80. doi: 10.1148/radiol.13120789. Epub 2013 Jun 14.
Pan D, Cai X, Yalaz C, Senpan A, Omanakuttan K, Wickline SA, Wang LV, Lanza GM. Photoacoustic sentinel lymph node imaging with self-assembled copper neodecanoate nanoparticles. ACS Nano. 2012 Feb 28;6(2):1260-7. doi: 10.1021/nn203895n. Epub 2012 Jan 20.
Boles KS, Schmieder AH, Koch AW, Carano RA, Wu Y, Caruthers SD, Tong RK, Stawicki S, Scott MJ, Zhang H, Reynolds BA, Wickline SA, Lanza GM. MR angiogenesis imaging with Robo4- vs. alphaVbeta3-targeted nanoparticles in a B16/F10 mouse melanoma model. FASEB J. 2010 Nov;24(11):4262-70. doi: 10.1096/fj.10-157933. Epub 2010 Jun 28.
Pan D, Pramanik M, Senpan A, Wickline SA, Wang LV, Lanza GM. A facile synthesis of novel self-assembled gold nanorods designed for near-infrared imaging. J Nanosci Nanotechnol. 2010 Dec;10(12):8118-23.
Kassner A, Thornhill RE, Liu F, Winter PM, Caruthers SD, Wickline SA, Lanza GM. Assessment of tumor angiogenesis: dynamic contrast-enhanced MRI with paramagnetic nanoparticles compared with Gd-DTPA in a rabbit Vx-2 tumor model. Contrast Media Mol Imaging. 2010 May-Jun;5(3):155-61. doi: 10.1002/cmmi.380.
Inventor Bio: Gregory M. Lanza
https://cardiology.wustl.edu/faculty/gregory-m-lanza-md-phd-facc/
