Polyethylene glycol based oligomers for coating nanoparticles, nanoparticles coated therewith, and related methods
Patent Number: US9446152
Executive Summary:
General Description:
The PEG-based oligomers anchored on metal nanoparticles render them hydrophilic, stable over a broad range of biological conditions, and surface reactive to allow bioconjugation with specific biological molecules, like proteins or peptides.
Scientific Progress:
Nanoparticles coated with oligoPEG-Dopamine were prepared and tested in vitro. The coating provides rapid ligand exchange and stability over a broad pH range.
Future Directions:
Strengths:
Weaknesses:
Patent Status:
Legal Status: Active
Publications:
Zhan N, Palui G, Kapur A, Palomo V, Dawson PE, Mattoussi H. Controlling the Architecture, Coordination, and Reactivity of Nanoparticle Coating Utilizing an Amino Acid Central Scaffold. J Am Chem Soc. 2015 Dec 30;137(51):16084-97. doi: 10.1021/jacs.5b10359. Epub 2015 Dec 18.Wang W, Aldeek F, Ji X, Zeng B, Mattoussi H.
A multifunctional amphiphilic polymer as a platform for surface-functionalizing metallic and other inorganic nanostructures. Faraday Discuss. 2014;175:137-51. doi: 10.1039/c4fd00154k.Zhan N, Palui G, Merkl JP, Mattoussi H.
Bio-orthogonal Coupling as a Means of Quantifying the Ligand Density on Hydrophilic Quantum Dots. J Am Chem Soc. 2016 Mar 9;138(9):3190-201. doi: 10.1021/jacs.5b13574. Epub 2016 Feb 26.
Stewart MH, Susumu K, Mei BC, Medintz IL, Delehanty JB, Blanco-Canosa JB, Dawson PE, Mattoussi H. Multidentate poly(ethylene glycol) ligands provide colloidal stability to semiconductor and metallic nanocrystals in extreme conditions. J Am Chem Soc. 2010 Jul 21;132(28):9804-13. doi: 10.1021/ja102898d.
Na HB, Palui G, Rosenberg JT, Ji X, Grant SC, Mattoussi H. Multidentate catechol-based polyethylene glycol oligomers provide enhanced stability and biocompatibility to iron oxide nanoparticles. ACS Nano. 2012 Jan 24;6(1):389-99. doi: 10.1021/nn203735b. Epub 2011 Dec 29.
Ji X, Palui G, Avellini T, Na HB, Yi C, Knappenberger KL Jr, Mattoussi H. On the pH-dependent quenching of quantum dot photoluminescence by redox active dopamine. J Am Chem Soc. 2012 Apr 4;134(13):6006-17. doi: 10.1021/ja300724x. Epub 2012 Mar 22.
Palui G, Na HB, Mattoussi H. Poly(ethylene glycol)-based multidentate oligomers for biocompatible semiconductor and gold nanocrystals. Langmuir. 2012 Feb 7;28(5):2761-72. doi: 10.1021/la203968t. Epub 2012 Jan 23.
Inventor Bio: Hedi Mattoussi
https://www.chem.fsu.edu/~mattoussi/
Executive Summary:
- Invention Type: Diagnostic/Therapeutic
- Patent Status: US Grant
- Patent Link: https://patents.google.com/patent/US9446152/
- Research Institute: Florida State University
- Disease Focus: Cancer
- Basis of Invention: Nanoparticles coatings that are water dispersible
- How it works: The nanoparticle coatings comprise a polyacrylic acid based backbone onto which PEG-based oligomers are appended. The PEG-based oligomers provide reactive sites for binding other ligands to the coating
- Lead Challenge Inventor: Hedi Mattoussi
- Inventors: Hedi Mattoussi, Goutam Palui, Hyon Bin Na
- Development Stage: in vitro
- Novelty:
- Composition of the coating
- Clinical Applications:
- Targeted drug delivery or imaging
General Description:
The PEG-based oligomers anchored on metal nanoparticles render them hydrophilic, stable over a broad range of biological conditions, and surface reactive to allow bioconjugation with specific biological molecules, like proteins or peptides.
Scientific Progress:
Nanoparticles coated with oligoPEG-Dopamine were prepared and tested in vitro. The coating provides rapid ligand exchange and stability over a broad pH range.
Future Directions:
- In vivo validation
Strengths:
- Composition of the coating to allow stable water dispersion and reduce non-specific interactions once introduced in a biological system
- The possibility to anchor different type of conjugates
Weaknesses:
- Competition with other nanoparticles coating
Patent Status:
Legal Status: Active
- Priority date: 2011.09.09
- Filing date: 2015.08.28
- Publication date: 2016.09.20
- Grant date: 2016.09.20
Publications:
Zhan N, Palui G, Kapur A, Palomo V, Dawson PE, Mattoussi H. Controlling the Architecture, Coordination, and Reactivity of Nanoparticle Coating Utilizing an Amino Acid Central Scaffold. J Am Chem Soc. 2015 Dec 30;137(51):16084-97. doi: 10.1021/jacs.5b10359. Epub 2015 Dec 18.Wang W, Aldeek F, Ji X, Zeng B, Mattoussi H.
A multifunctional amphiphilic polymer as a platform for surface-functionalizing metallic and other inorganic nanostructures. Faraday Discuss. 2014;175:137-51. doi: 10.1039/c4fd00154k.Zhan N, Palui G, Merkl JP, Mattoussi H.
Bio-orthogonal Coupling as a Means of Quantifying the Ligand Density on Hydrophilic Quantum Dots. J Am Chem Soc. 2016 Mar 9;138(9):3190-201. doi: 10.1021/jacs.5b13574. Epub 2016 Feb 26.
Stewart MH, Susumu K, Mei BC, Medintz IL, Delehanty JB, Blanco-Canosa JB, Dawson PE, Mattoussi H. Multidentate poly(ethylene glycol) ligands provide colloidal stability to semiconductor and metallic nanocrystals in extreme conditions. J Am Chem Soc. 2010 Jul 21;132(28):9804-13. doi: 10.1021/ja102898d.
Na HB, Palui G, Rosenberg JT, Ji X, Grant SC, Mattoussi H. Multidentate catechol-based polyethylene glycol oligomers provide enhanced stability and biocompatibility to iron oxide nanoparticles. ACS Nano. 2012 Jan 24;6(1):389-99. doi: 10.1021/nn203735b. Epub 2011 Dec 29.
Ji X, Palui G, Avellini T, Na HB, Yi C, Knappenberger KL Jr, Mattoussi H. On the pH-dependent quenching of quantum dot photoluminescence by redox active dopamine. J Am Chem Soc. 2012 Apr 4;134(13):6006-17. doi: 10.1021/ja300724x. Epub 2012 Mar 22.
Palui G, Na HB, Mattoussi H. Poly(ethylene glycol)-based multidentate oligomers for biocompatible semiconductor and gold nanocrystals. Langmuir. 2012 Feb 7;28(5):2761-72. doi: 10.1021/la203968t. Epub 2012 Jan 23.
Inventor Bio: Hedi Mattoussi
https://www.chem.fsu.edu/~mattoussi/
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